Dr. Paul Offit, FDA panel member, gives his view of what happened.
https://www.nejm.org/doi/full/10.1056/NEJMp2215780
New England Journal of Medicine.
"the virus evolved...
"Why did the strategy for significantly increasing BA.4 and BA.5 neutralizing antibodies using a bivalent vaccine fail? The most likely explanation is imprinting. The immune systems of people immunized with the bivalent vaccine, all of whom had previously been vaccinated, were primed to respond to the ancestral strain...
"By December 2022, the BA.4 strain was no longer circulating, and BA.5 accounted for less than 25% of circulating SARS-CoV-2 strains, having been partially replaced by more immune-evasive strains, such as BQ.1, BQ.1.1, BF.7, XBB, and XBB.1...
"...booster dosing is probably best reserved for the people most likely to need protection against severe disease...I believe we should stop [boosting] healthy, young people..."

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