This is pretty much a random bug which will make it difficult to troubleshoot on the servers / host routers.
I ran into this today. First I was connected via my VPN and I was getting this message:
Connection Error (SSLHandshakeExecption: Remote host closed connection during handshake, SSL peer shut down incorrectly)
I restarted Vuse and the errors still happened. I then exited Vuse and disabled my VPN. Next I was getting the Timeout error. I shut down Vuse and enabled my VPN again and I had the Timeout error. I restarted Vuse again and it worked.
I know how hard it is to troubleshoot an issue like this when you can not reliably reproduce the error. I wish the Tech team good luck in tracing this bug.