I have been using Retin A .05% since 1990. Make sure you face is completely dry before applying. Do not use more than an english pea size dab of the cream. The first six weeks are the worst, but will resolve. Use a mild cleanser, sun screen, try using every other day until the initial adjustment period resolves. Moisturizer is essential, but try and stay away from ones loaded with AHAs until you adapt to the treatment. I am now 49 and rarely does anyone guess I am over 33 years old. That's without any cosmetic surgery.