estrogen for males, is high risk
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"Emerging and accumulating safety signals for the use of estrogen among transgender women"
https://link.springer.com/article/10.1007/s44192-025-00216-3
Title is off - they're males with gender dysphoria.
But, info here is: Estrogen supplements give males 3x higher risk of cardiovascular & stroke events. 26x higher risk of testicular cancer. 40x higher risk of breast cancer, cognitive impairment, & autoimmune disease.