Serum neutralizing activities homosexual male cohort infected with HIV-1
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PLoS One
http://www.researchgate.net/profile/Shan_Lu2/publication/232649767_Serum_Neutralizing_Activities_from_a_Beijing_Homosexual_Male_Cohort_Infected_with_Different_Subtypes_of_HIV-1_in_China/links/0deec521127d166010000000?ev=pub_ext_doc_dl&origin=publication_detail&inViewer=true
Protective antibodies play a critical role in an effective HIV vaccine; however, eliciting antibodies to block infection by viruses from diverse genetic subtypes remains a major challenge. As the world's most populous country, China has been under the threat of at least three major subtypes of circulating HIV-1 viruses. Understanding the cross reactivity and specificities of serum antibody responses that mediate broad neutralization of the virus in HIV-1 infected Chinese patients will provide valuable information for the design of vaccines to prevent HIV-1 transmission in China. Sera from a cohort of homosexual men, who have been managed by a major HIV clinical center in Beijing, China, were analyzed for cross-sectional neutralizing activities against pseudotyped viruses expressing Env antigens of the major subtype viruses (AE, BC and B subtypes) circulating in China. Neutralizing activities in infected patients' blood were most capable of neutralizing viruses in the homologous subtype; however, a subset of blood samples was able to achieve broad neutralizing activities across different subtypes. Such cross neutralizing activity took 1-2 years to develop and CD4 binding site antibodies were critical components in these blood samples. Our study confirmed the presence of broadly neutralizing sera in China's HIV-1 patient population. Understanding the specificity and breadth of these neutralizing activities can guide efforts for the development of HIV vaccines against major HIV-1 viruses in China. -
Way to scientific for most non medical people to understand.
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still they are " medical" people around here interested to read it :hug2:
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Way to scientific for most non medical people to understand.
still they are " medical" people around here interested to read it :hug2:
:blink:
